RecruitingAlcohol Use DisorderWeight LossBariatric Surgery Patients
Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS)
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this research study is to evaluate the feasibility of treating Alcohol Use Disorder with Semaglutide after metabolic and bariatric surgery in adults with overweight or obesity.
Sponsor: Yale University
You may qualify if…
- ✓ Provision of signed and dated informed consent form
- ✓ Stated willingness to comply with all study procedures and availability for the duration of the study (up to 6 months: 3-month treatment plus 3-month follow up)
- ✓ Age 18 and older
- ✓ Have a BMI ≥30 (or BMI ≥27 with a medical comorbidity) and BMI ≤50 kg/m2
- ✓ Have had laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy within the past seven years
- ✓ Meet current DSM-5 criteria for Alcohol Use Disorder
- ✓ Be an otherwise healthy subject without uncontrolled medical problems, as determined by the study physician and medical co-investigators
- ✓ Read, comprehend, and write English at a sufficient level to complete study-related materials
You may not qualify if…
- ✕ Any of the following: myocardial infarction, stroke, hospitalization for unstable angina, or transient ischemic attack within the past 60 days prior to screening
- ✕ History or presence of chronic or recurrent pancreatitis
- ✕ History of malignant neoplasms within the past 5 years prior to screening
- ✕ Personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2
- ✕ Is currently using other medications for weight loss or other GLP-1 receptor agonists
- ✕ Has a history of allergy or sensitivity to Semaglutide
- ✕ Has a co-existing psychiatric condition that requires hospitalization or more intensive treatment (such as bipolar mood disorders, psychotic illnesses, or severe depression)
- ✕ Has untreated hypertension with a seated systolic blood pressure \> 160 mmHg, diastolic blood pressure \> 100 mmHg, or heart rate \> 100 beats/minute
Where it's recruiting
Connecticut
New Haven
Source: ClinicalTrials.gov · NCT07223983 · last updated 2026-05-12