Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main questions it aims to answer are: Does the intervention improve insulin sensitivity (how the body uses glucose)? Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)? What changes occur in brain glucose uptake (FDG-PET)? Participants will: Receive the intervention once a week for 6 months, with each session lasting up to 2 hours Complete cognitive assessments. Adverse events will be assessed throughout the study.
Sponsor: Pennington Biomedical Research Center
You may qualify if…
- ✓ Mini Mental State Examination (MMSE) score \< 25
You may not qualify if…
- ✕ On daily medication for the specific treatment of anxiety including benzodiazepines.
- ✕ An infant, child, or teenager
- ✕ A pregnant woman
- ✕ A prisoner
- ✕ Having any condition that impedes testing of the study hypothesis or are otherwise deemed to be unsuitable (determined by the investigative team).
Where it's recruiting
Baton Rouge
Source: ClinicalTrials.gov · NCT07265323 · last updated 2025-12-04