RecruitingAlzheimer s DiseaseAlzheimer Dementia (AD)Alzheimer Dementia
Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia
Eligible age
All ages
Accepts
All genders
Locations
0 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed AD/vascular dementia
Sponsor: Sunnybrook Health Sciences Centre
You may qualify if…
- ✓ Alzheimer's disease or mixed Alzheimer's disease and vascular disease
- ✓ MMSE score 10-28 inclusive
- ✓ Clinically significant apathy
- ✓ Stable dose of psychotropic medication
- ✓ Care partner must spend at least 10hrs/week with the participant
You may not qualify if…
- ✕ Major Depressive Episode
- ✕ Clinically significant agitation, delusions, hallucinations
- ✕ Currently talking a dopaminergic agent other than methylphenidate
- ✕ Failure to clear the TMS adult safety scale (e.g. unapproved pacemakers, metallic implants, history of epilepsy)
- ✕ Central nervous system abnormalities (other than Alzheimer's disease) deemed clinically significant by study physician or seizures
- ✕ Any condition that in the opinion of the study physician, makes it medically unsafe for the patient to enroll in the trial
Source: ClinicalTrials.gov · NCT07279740 · last updated 2025-12-12