RecruitingObesityOverweight

Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

Eligible age

18+ yrs

Accepts

All genders

Locations

18 states

Healthy volunteers

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About this study

The primary objective of the study is to determine the effects of KAI-9531 subcutaneous (SC) injection once weekly compared to placebo on percent change in body weight.

Sponsor: Kailera

You may qualify if…

✓ BMI ≥30 kg/m\^2 or BMI ≥27 kg/m\^2 and previously diagnosed with at least 1 of the following:
✓ 1. hypertension,
✓ 2. dyslipidemia,
✓ 3. obstructive sleep apnea, or
✓ 4. cardiovascular (CV) disease.
✓ History of at least 1 self-reported unsuccessful effort to lose weight with diet and exercise within the prior 6 months.

You may not qualify if…

✕ Current diagnosis or history of diabetes mellitus.
✕ Started medications within 3 months prior to Screening that may cause significant weight gain, including, but not limited to, tricyclic antidepressants, atypical antipsychotics, and mood stabilizers.
✕ Unstable weight defined as self-reported change in body weight exceeding 5% within 3 months prior to Screening.
✕ Family or personal history of multiple endocrine neoplasia Type 2 or medullary thyroid cancer.
✕ Uncontrolled hypertension or unstable cardiovascular disease.
✕ History of chronic or acute pancreatitis.
✕ Known clinically significant gastric-emptying abnormality or chronic treatment with medications that directly affect gastrointestinal motility.
✕ History of suicide attempt.