Continuous Positive Airway Pressure, Arousability and Links to Mechanisms in Obstructive Sleep Apnea
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The study design is a randomized, controlled clinical trial to test the hypothesis that arousal threshold (ArTH) will affect how individuals with obstructive sleep apnea (OSA, Apnea-Hypopnea Index (AHI) of 10/hour of higher) respond to CPAP therapy regarding adherence and cognitive function (executive function). Investigators hypothesize that raising ArTH with eszopiclone will improve adherence to CPAP and neurocognitive function with CPAP therapy. Investigators also hypothesize that a lower baseline ArTH is associated with worse CPAP adherence, while a higher baseline ArTH is associated with improved neurocognitive outcomes with CPAP therapy.
Sponsor: Yale University
You may qualify if…
- ✓ Able to provide informed consent.
- ✓ Clinically confirmed new diagnosis of OSA:
- ✓ 1. Polysomnography AHI ≥ 10 per hour of sleep and/or
- ✓ 2. Home sleep apnea testing, respiratory even index, REI ≥ 10 per hour of recording
You may not qualify if…
- ✕ Known non-OSA related conditions associated with sleep-disordered breathing (e.g., a central disorder of hypersomnolence, neurological, neuromuscular, or pulmonary disorder)
- ✕ Use of sleep-inducing medications (e.g., other non-benzodiazepine sedative hypnotic-drugs \[e.g., zoldpidem\], benzodiazepines, non-selective antihistamines, trazodone, opiates, barbituates)
- ✕ Known hypersensitivity reaction to eszopiclone
- ✕ Contraindications to its use based on medical history or function (e.g., dizziness at baseline or established mobility problems or imbalance)
- ✕ History of complex sleep behaviors (e.g., NREM or REM parasomnias)
- ✕ Concomitant use of ≥ 2 servings of alcohol per night or other CNS depressant for 2 weeks prior or throughout the study
- ✕ Sleep opportunity of less than 7 hours
- ✕ Severe active depression or other mental health disorders (e.g., schizophrenia, bipolar disorder, personality disorder).
Where it's recruiting
North Haven
Source: ClinicalTrials.gov · NCT07332442 · last updated 2026-06-03