RecruitingAsthmaEosinophilic Granulomatosis With Polyangiitis (EGPA)Hypereosinophilic Syndrome (HES)
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
Eligible age
6+ yrs
Accepts
All genders
Locations
8 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The rationale of the roll-over study (ROSY) is to provide continuous access to study treatment for participants who have completed or exited a parent study and are deemed appropriate for continued benralizumab treatment, as judged by the Investigator, while monitoring long-term safety and tolerability of benralizumab.
Sponsor: AstraZeneca
You may qualify if…
- ✓ 1\. Provision of signed and dated written ICF.
- ✓ 2\. Participants completing minimum required OLE period of a parent study and judged by the Investigator to benefit from continued treatment.
- ✓ 3\. Participants must agree to follow the contraception requirements as per their respective parent protocols from study inclusion up to 12 weeks after the last dose of study treatment.
- ✓ 4\. Participants without childbearing potential at enrolment must agree to start appropriate contraception if childbearing potential develops during the study and up to 12 weeks after the last dose of study treatment.
- ✓ 5\. Participants who are unable to access commercially available benralizumab and clinically indicated for continuation.
You may not qualify if…
- ✕ 1\. Ongoing, unresolved AE requiring interruption of treatment at the end of the prior parent study (ie, when the parent study is either completed or closed) that in the Investigator's opinion would prevent restarting benralizumab.
- ✕ 2\. Participants who are planning to use live/live-attenuated vaccines.
- ✕ 3\. Participants who are planning to use biologic therapies, including B-cell therapies with the exception for the treatment of co-morbidities where no alternative medicine is available.
- ✕ 4\. Participants with any medical condition (such as cancer or viral infections \[hepatitis\]) or psychiatric condition that, in the opinion of the Investigator, could jeopardise or would compromise the participant's ability to participate in this study as determined by the Investigator based on protocol required assessments.
- ✕ 5\. Concurrently enrolled in any clinical study (other than a parent study).
- ✕ 6\. Participants who discontinued the parent study prior to completing the minimum OLE or treatment period.
- ✕ 7\. Local access to commercially available benralizumab.
Where it's recruiting
Colorado
Aurora
Maryland
Bethesda
Michigan
Ann Arbor
New Jersey
Northfield
New York
The Bronx
North Carolina
Durham
Ohio
Cleveland
Utah
Salt Lake City
Source: ClinicalTrials.gov · NCT07444567 · last updated 2026-08-19