RecruitingPost Traumatic Stress Disorder

An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

Eligible age

18+ yrs

Accepts

All genders

Locations

20 states

Healthy volunteers

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About this study

This study is evaluating the safety and efficacy of TSND-201 in adults with PTSD. Eligible participants will enter a 4-week Treatment Period where they will be randomized 1:1:1 to receive one of two doses of TSND-201 or placebo, once per week. Following the Treatment Period, participants will enter an 8-week Follow-up Period.

Sponsor: Transcend Therapeutics

You may qualify if…

✓ Meets the DSM-5 criteria for current PTSD diagnosis, with a symptom duration of at least 6 months.
✓ Tried at least one pharmacological treatment for PTSD or trauma-focused psychotherapy.
✓ Proficient in communication (verbal and reading) to complete interviews and written questionnaires.
✓ Free from any other clinically significant illness or disease.

You may not qualify if…

✕ Primary diagnosis of any other DSM-5 disorder.
✕ Body mass index (BMI) \<18 kg/m2 or ≥40 kg/m2.
✕ Unable to refrain from nicotine use for at least 8 hours.
✕ Use of prohibited concomitant medications or therapies.
✕ Current or previous history of clinically significant cardiovascular (including current uncontrolled hypertension) / cerebrovascular conditions.