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RecruitingMild Depression

Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth

Eligible age

15–24 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

The primary goal is to investigate to what extent changes in glutamate and glutathione modulation and functional integration between brain networks associated with emotion and attention regulation are associated with treatment response in mildly depressed youth.

Sponsor: University of Cincinnati

You may qualify if…

  • ✓ 1. age between 15 years, 0 months to 24 years, 11 months old;
  • ✓ 2. presenting with mild depression, defined by meeting DSM-5 criteria for a current major depressive episode, mild severity, or persistent depressive disorder, or other specified depressive disorder (depressive episode with insufficient symptoms to meet criteria for a major depressive episode);
  • ✓ 3. medication-naïve or medication free for at least 5 half-lives since the last use of a psychoactive medication, with the exception of stimulants for ADHD;
  • ✓ 4. if on ADHD stimulant medication over 2 months prior to screening, willing to maintain stimulant dose constant during the study participation;
  • ✓ 5. Tanner stage greater than or equal to III;

You may not qualify if…

  • ✕ 1. significant suicidal risk, defined by suicidal ideation of type 3, 4 or 5 on the Columbia Suicide Severity Rating Scale (C-SSRS) in the past 3 months, or any lifetime suicidal attempts;
  • ✕ 2. current major depressive episode, moderate or severe
  • ✕ 3. current or lifetime history of manic or hypomanic episodes, and/or diagnosis of bipolar disorder;
  • ✕ 4. current or lifetime history of psychotic disorders, and/or prior diagnosis of schizophrenia spectrum disorders;
  • ✕ 5. active or current substance use disorders in the last 3 months, except cannabis or alcohol use disorder, mild;
  • ✕ 6. diagnosis of autism spectrum disorder, pervasive developmental disorder, obsessive-compulsive disorder, post-traumatic stress disorders, Tourette's syndrome
  • ✕ 7. any contraindication to MRI scanning;
  • ✕ 8. pregnancy;

Where it's recruiting

Ohio

Cincinnati

Source: ClinicalTrials.gov · NCT07464886 · last updated 2026-03-11