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RecruitingAnxietyPTSD

Temporal Interference in Psychiatry (TIP): Neuromodulation Using Temporal Interference

Eligible age

18–65 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

This study aims to understand the neural, behavioral and clinical effects of temporal interference (TI), a type of neuromodulation method, in healthy populations and in individuals with anxiety and stress-related conditions.

Sponsor: Emory University

You may qualify if…

  • ✓ Written informed consent.
  • ✓ Fluent English speaker.
  • ✓ Both sexes and all ethnic origins, between 18 and 65 years old.
  • ✓ Absence of current moderate to severe illicit drug use as assessed by subject history (AUDIT\>=8 and/or DAST\>2).

You may not qualify if…

  • ✕ Pregnant or currently breast-feeding women or any woman of childbearing potential who is seeking to become pregnant or suspects that she may be pregnant, as assessed by subject report and/or urine pregnancy screen.
  • ✕ Contraindications to MRI scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia, as assessed with the standard MRI screening form from the CABI, FERN or CSI.
  • ✕ Unable to fit comfortably in the scanner.
  • ✕ Contraindication to TI and/or TMS (including history of epilepsy, metallic implants in the head and/or neck, brain stimulators, vagus nerve stimulators, VP shunt, pacemakers)
  • ✕ Current use of medications that may increase the risk of seizures (e.g., bupropion, varenicline, chlorpromazine, theophylline).
  • ✕ History or current serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease, as assessed by subject history.
  • ✕ History of head injury resulting in more than brief loss of consciousness, as assessed by subject history.
  • ✕ Current cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine), as assessed by subject history.

Where it's recruiting

Georgia

Atlanta

Source: ClinicalTrials.gov · NCT07558759 · last updated 2026-07-15