Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery
Eligible age
18–65 yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
No
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About this study
The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery. The main question it aims to answer : -Will there be a difference in the perioperative stress between patients receiving OFA with and without desflurane? Participants will undergoing sleeve gastrectomy or gastric by pass, will be administered OFA with and without desflurane and blood tests (cortisole, ACTH,dopamine, PRL, adrenaline, noradrenaline, lactate) will be collected perioperatively to compare stress in the two groups.
Sponsor: G.Gennimatas General Hospital
You may qualify if…
- ✓ Signed Informed Consent
- ✓ ASA II-III
- ✓ Morbid obesity confirmed diagnosis and approval for surgical treatment
- ✓ Laparoscopic sleeve gastrectomy (LSG) or Gastric By pass (R-Y By pass /SASI/SADI AND one anastomosis by pass )
- ✓ Preop respiratrory assessment conducted
- ✓ Adequate organ and bone marrow function
You may not qualify if…
- ✕ Patients declining or withdrawing consent
- ✕ Patients unsuitabe with regards to compliance to treatment, according to the researcher's assessment
- ✕ Bradycardia, AV block, , postural hypotension
- ✕ QTcF\>470msec
- ✕ Known allergy or hypersensitiity to any of the medications administered
- ✕ Stop-BANG score \>6
- ✕ Intraoperative administration of more than 8mg of prednisolone or equivalent
- ✕ Patients who have received corticosteroids for durations \>3 weeks at any point in their lifetime
Source: ClinicalTrials.gov · NCT07568938 · last updated 2026-05-06