RecruitingDiabetes Mellitus, Type 2

A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes

Eligible age

10–17 yrs

Accepts

All genders

Locations

10 states

Healthy volunteers

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About this study

This study looks at how well a medicine called orforglipron works compared to another medicine called dulaglutide in pediatric participants aged 10 to less than 18 years with type 2 diabetes. The study will also check how safe these medicines are and how the body processes them. Participation in the study will last about 61 weeks.

Sponsor: Eli Lilly and Company

You may qualify if…

✓ Have type 2 diabetes treated with diet and exercise and metformin and/or basal insulin
✓ Have HbA1c \> 6.5% to ≤ 11.0% at screening
✓ Have a body weight ≥50 kilograms (kg) (110 pounds) and a body mass index (BMI) of \>85th percentile

You may not qualify if…

✕ Have type 1 diabetes
✕ After the type 2 diabetes diagnosis, have a history of diabetic ketoacidosis or hyperosmolar syndrome
✕ Have had at least one episode of severe hypoglycemia and/or at least one episode of hypoglycemic unawareness within the last 6 months before screening
✕ Have a history of pancreatitis or gallbladder disease
✕ Have a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2)
✕ Have received treatment with any glucose-lowering agent(s) other than metformin, basal insulin, or (SGLT2) inhibitors within 90 days prior to screening
✕ Have been treated with prescription drugs or over-the-counter medications that promote weight loss within 90 days prior to screening