RecruitingNon Small Cell Lung CancerCardiotoxicityLocally Advanced Non-Small Cell Lung Cancer
Prospective Study on Radiation Induced Cardiotoxicity Assessed By PET-CT for Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Prospective clinical study designed to evaluate damage to the heart after receiving standard of care chemotherapy and radiation therapy for locally advanced Non-Small Cell Lung Cancer (NSCLC).
Sponsor: Indiana University
You may qualify if…
- ✓ 1. Age ≥ 18 at time of consent
- ✓ 2. Ability to provide written informed consent and HIPAA authorization
- ✓ 3. Stage III NSCLC per AJCC 8th edition guideline, confirmed by pathological diagnosis and PET/CT.
- ✓ 4. To receive standard definitive concurrent chemoradiation therapy per NCCN guidelines.
- ✓ 5. Tumor estimated to be within 2cm of heart contour or anticipated MHD\>10Gy per treating physician.
You may not qualify if…
- ✕ 1. Patients treated with stereotactic body radiotherapy (SBRT).
- ✕ 2. Prior thoracic radiotherapy.
- ✕ Exclusion for Coronary computed tomography angiography (CCTA)
- ✕ 1. History of a severe anaphylactic reaction to iodinated contrast.
- ✕ 2. Renal insufficiency (defined as estimated CrCl less than 30 mL/min).
- ✕ 3. Inability to hold breath for more than 5 seconds.
- ✕ 4. Patients on radioactive iodine therapy.
- ✕ Exclusion for 18F-Flurpiridaz PET/CT Test
Where it's recruiting
Indiana
Indianapolis
Source: ClinicalTrials.gov · NCT07761910 · last updated 2026-08-12