Personalized Fluid Resuscitation in the Emergency Department: A Pilot Trial
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The goal of this pilot clinical trial is to learn if a fluid assessment using non-invasive cardiac output monitoring (NICOM) is helpful for patients with sepsis who have low blood pressure in the Emergency Department (ED). The study will measure whether the NICOM assessment changes fluid resuscitation practices and is feasible in the ED setting. All patients will receive standard medical care. Patients assigned to the NICOM group will receive a one-time, non-invasive bedside fluid assessment using NICOM, in addition to standard care, and the results of the fluid assessment will be provided to the treating physician.
Sponsor: Intermountain Health Care, Inc.
You may qualify if…
- ✓ 1. Adult patient being treated in the Intermountain Medical Center ED
- ✓ 2. Patient has suspected sepsis. Suspected sepsis can be identified by a positive sepsis screen (standard screen completed by ED triage nurse), an active sepsis alert (which is triggered based on qualifying information or active by an ED nurse), or clinician report that patient has possible sepsis
- ✓ 3. Patient is hypotensive OR has an initial lactate ≥4 mmol/L at the time of enrollment. Hypotension is defined as mean arterial pressure (MAP) \<65 mmHg or systolic blood pressure (SBP) \<90mmHg or patient is on vasopressors at time of enrollment.
You may not qualify if…
- ✕ 1. Age \< 18 years
- ✕ 2. Known pregnant patients
- ✕ 3. Patients who are known to be incarcerated
- ✕ 4. A trained and delegated study team member is not available to perform the NICOM fluid assessment
- ✕ 5. Patient has been in the ED for \>6 hours or was transferred from an outside ED
- ✕ 6. Patient has already received 30 ml/kg IV fluid or has this fluid volume ordered. Weight-based fluid dosing is calculated based on actual body weight for BMI \<30kg/m2 and ideal body weight for BMI ≥30 kg/m2
- ✕ 7. Known clinical diagnosis of a condition potentially altering risk/benefit profile of NICOM-based fluid assessment, which may include
- ✕ 1. Hemorrhagic shock (i.e.., active hemorrhage)
Where it's recruiting
Murray
Source: ClinicalTrials.gov · NCT07779720 · last updated 2026-08-25