RecruitingHypertensionAldosterone DisorderCardiovascular Disease (CVD)
REFOCUS-HTN US-WEST: A Data Infrastructure to Characterize Individuals With Hypertension
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The goal of the REFOCUS-HTN US-WEST program is to gain a better understanding of the role of a hormone called aldosterone in the development of hypertension. The SCALED sub-study is an observational cohort study that will enroll from REFOCUS-HTN cohort for prospective data collection.
Sponsor: Kaiser Permanente
You may qualify if…
- ✓ The SCALED Cohort will be identified from the REFOCUS-HTN Cohort which includes men and women ≥ 18 years of age with established hypertension in the KPNC EHR from January 2012 through March 31, 2029. Established hypertension will be defined as one of the following:
- ✓ ≥1 outpatient, non-emergency department diagnosis of hypertension;
- ✓ ≥2 consecutive outpatient measures of systolic blood pressure ≥130 mmHg at least 90 days apart;
- ✓ ≥2 consecutive outpatient measures of diastolic blood pressure ≥80 mmHg at least 90 days apart.
- ✓ Additional Eligibility Criteria for SCALED:
- ✓ Hypertension diagnosis within the past 18 months prior to screening.
- ✓ At least 6 months of continuous health plan coverage prior to initial visit.
You may not qualify if…
- ✕ Diagnosed cause of secondary hypertension from drug or alcohol induced, or renovascular hypertension;
- ✕ Bariatric surgery or GLP1 prescription in the last 12 months;
- ✕ Exposure to an aldosterone synthase inhibitor or a mineralocorticoid receptor antagonist in the last 12 weeks;
- ✕ Last known estimated glomerular filtration rate \< 45 mL/min/1.73m2 (according to the CKD-EPI equation) at the time of screening;
- ✕ Kidney transplant;
- ✕ Currently receiving dialysis;
- ✕ Current enrollment in any cardiovascular or blood pressure interventional trial.
Where it's recruiting
California
Oakland
Source: ClinicalTrials.gov · NCT07780500 · last updated 2026-08-21