Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
Eligible age
40+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
Sponsor: University of Chicago
You may qualify if…
- ✓ Age ≥ 40
- ✓ Clinical diagnosis of knee OA with predominant medial compartment symptoms
- ✓ Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
- ✓ Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
- ✓ Able to provide informed consent
- ✓ Able to complete phone, email, or MyChart follow-ups in English
You may not qualify if…
- ✕ Predominant lateral compartment OA or patellofemoral-only OA
- ✕ Inflammatory arthritis (RA, gout flare, etc.)
- ✕ Suspected or confirmed joint infection or overlying cellulitis
- ✕ Prior knee arthroplasty on the index knee
- ✕ Planned surgery for index knee within 12-week follow-up
- ✕ Inability to complete follow-up assessments
- ✕ Other clinician-determined contraindication to CSI
Where it's recruiting
Bolingbrook · Chicago · La Grange · Orland Park …
Source: ClinicalTrials.gov · NCT07804446 · last updated 2026-09-04