Sex Hormones and Aging
Eligible age
50–70 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training. Age-related declines in neuromuscular function are especially pronounced in females, potentially due to the sharp drop in estradiol after menopause. This project will compare postmenopausal females who have not taken hormonal therapy (HT) to age-matched females taking HT.
Sponsor: University of Michigan
You may not qualify if…
- ✕ Females who are pregnant or likely to be pregnant. Female subjects of childbearing age will be asked of the possibility of pregnancy and will be excluded from the study if they are pregnant or become pregnant during the study.
- ✕ Females who are not currently taking HT but have taken HT in the past 5 years.
- ✕ Severe obesity (body mass index, BMI, \> 45 kg/m2): this will be calculated from measured height and weight
- ✕ Untreated hypothyroidism
- ✕ Uncontrolled blood pressure (\>160/100 mmHg at rest)
- ✕ Epilepsy or increased risk of seizures
- ✕ Metal implants in the body, excluding the mouth
- ✕ Head injury in the past 6 months
Where it's recruiting
Ann Arbor
Source: ClinicalTrials.gov · NCT07848438 · last updated 2026-09-30