HBOT Effects on First Responders' Cognition and Well-Being
Eligible age
18–75 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The goal of this study is to examine changes in cognitive functioning and post-concussive symptoms following hyperbaric oxygen therapy (HBOT) in current and former first responders with a history of traumatic brain injury. The main questions it aims to answer are: 1. Do cognitive functioning and post-concussive symptoms change after 40 HBOT sessions? 2. Do symptoms of PTSD, depression, and anxiety, or quality of life, change after treatment? Approximately 54 participants will: * Complete medical and behavioral health screening. * Complete cognitive tests and questionnaires before and after treatment. * Receive 40 HBOT sessions at 2.0 atmospheres absolute (ATA), twice daily with at least four hours between sessions. All participants will receive HBOT. There is no comparison group, so the study cannot determine whether HBOT caused any observed changes.
Sponsor: Summit Hyperbarics and Wellness
You may qualify if…
- ✓ 1. Adults aged 18 to 75 years.
- ✓ 2. Current or former first responder.
- ✓ 3. Clinically diagnosed with a traumatic brain injury (TBI) and current or persistent post-concussive syndrome, as determined by a qualified health care professional.
- ✓ 4. Participants with comorbid PTSD, depression, or anxiety may be enrolled if all other eligibility criteria are met; these symptoms will be assessed as secondary/exploratory outcomes.
- ✓ 5. Ability to provide informed consent, including the ability to read, understand, and voluntarily sign the informed consent document.
- ✓ 6. Completion of baseline cognitive and psychological assessment measures as part of study enrollment procedures.
- ✓ 7. Presence of clinically significant symptoms resulting in functional impairment in occupational, social, or other key areas of functioning, as determined by clinical evaluation.
- ✓ 8. Sexually active female participants of childbearing potential and sexually active male participants with female partners of childbearing potential must agree to use an acceptable method of contraception for the duration of the study and for 30 days following the final HBOT session.
You may not qualify if…
- ✕ 1. Untreated pneumothorax
- ✕ 2. History of spontaneous pneumothorax
- ✕ 3. Severe sinus infection
- ✕ 4. Upper respiratory infection
- ✕ 5. Asymptomatic pulmonary lesions on chest x-ray
- ✕ 6. Uncontrollable high fever (greater than 39C)
- ✕ 7. History of chest or ear surgery
- ✕ 8. Congenital spherocytosis
Where it's recruiting
Boise
Source: ClinicalTrials.gov · NCT07852728 · last updated 2026-10-01