EXercise-induced PhysioLogical Adaptations In Neurological Disorders
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical exhaustion differ between patients with neurological diseases and healthy participants? * How does acute exercise affect brain function and other physiological biomarkers in participants with neurological diseases? Participants will take part in a single, one-day study visit and will be asked to: * Perform a standardized exercise test on a bicycle ergometer * Undergo a brain MRI (magnetic resonance imaging) scan, a blood draw, and autonomic measurements before and after the exercise test
Sponsor: Brigham and Women's Hospital
You may qualify if…
- ✓ 18 years or older
- ✓ Clinical diagnosis of one of the following neurological diseases: epilepsy, functional neurological disorder, mild cognitive impairment, dementia, Parkinson's disease, concussion, brain tumor \[for participants with neurological diseases\]
- ✓ No diagnosis of neurological disease \[for healthy control participants\]
You may not qualify if…
- ✕ Non-english speaking individuals
- ✕ Exercise contraindications (e.g., physical impairments limiting use of bicycle ergometer, acute infections, severe heart disease, uncontrolled hypertension, exercise associated seizures)
- ✕ Current use of medications for cardiac rhythm or rate control
- ✕ Magnetic resonance imaging (MRI) contraindications (e.g., electrical implants, ferromagnetic implants or objects, pregnancy)
Where it's recruiting
Boston
Source: ClinicalTrials.gov · NCT07883720 · last updated 2026-10-20